Human Gene Mapping 10

Human gene mapping.

Comparative mapping of human chromosome 10 to pig chromosomes 10 and 14.

Identification of predictive markers in QTL regions that impact production traits in commercial populations of swine is dependent on construction of dense comparative maps with human and mouse genomes. Chromosomal painting in swine suggests that large genomic blocks are conserved between pig and human, while mapping of individual genes reveals that gene order can be quite divergent. High-resolu...

Chromosomal mapping of the tankyrase gene in human and mouse.

Functional gene description: Tankyrase (TNKS) is a ovel gene with homology to both ankyrins and the cataytic domain of poly(ADP-ribose) polymerase (PARP) that as recently cloned using a yeast two-hybrid screen with he telomere-specific DNA binding protein TRF1 (1). ankyrase protein is located at telomeres, centrosomes, nd nuclear pore complexes (1; S. Smith and T. de Lange, n preparation). In v...

Mapping Gene Associations in Human Mitochondria using Clinical Disease Phenotypes

Nuclear genes encode most mitochondrial proteins, and their mutations cause diverse and debilitating clinical disorders. To date, 1,200 of these mitochondrial genes have been recorded, while no standardized catalog exists of the associated clinical phenotypes. Such a catalog would be useful to develop methods to analyze human phenotypic data, to determine genotype-phenotype relations among many...

Mapping the Genetic Architecture of Gene Expression in Human Liver

Genetic variants that are associated with common human diseases do not lead directly to disease, but instead act on intermediate, molecular phenotypes that in turn induce changes in higher-order disease traits. Therefore, identifying the molecular phenotypes that vary in response to changes in DNA and that also associate with changes in disease traits has the potential to provide the functional...